This study aimed to investigate the effect of the fluorosis on the reproductive and thyroid disorders through its biochemical, histopathological and immunohistochemical findings in one of fluoride endemic area in Egypt. They carried out on forty adult ewes and does which grouped into two groups. The 1st group (20 animals: 10 ewes and 10 does) was control group that brought from the Animal Reproduction Research Institute farm. The 2nd group was a fluoride group (20 animals: 10 ewes and 10 does) that brought from abattoir and farms in Alexandria dessert way, North cost and Alexandria Governorate. Excess water fluorosis (2.9 mg/L) caused a significant (p
Key words: Keywords: Biochemical, immunohistochemical, histopathology, fluoride, ovarian, uterine, steroid hormones, hypothyroidism.