Abstract

Aim: This study compared the Hemoglobin–Albumin–Lymphocyte–Platelet (HALP) index between individuals with schizophrenia and healthy controls and evaluated its discriminative performance in distinguishing schizophrenia.
Materials and Methods: Demographic and laboratory data from 69 patients with schizophrenia and 62 healthy controls were analyzed. A multivariable binary logistic regression model predicting schizophrenia diagnosis included logHALP, age, sex, smoking status, and C-reactive protein (CRP). Model discrimination was evaluated using receiver operating characteristic (ROC) analysis and the corresponding area under the curve (AUC). In the schizophrenia group, associations between the HALP index and cognitive performance or functional outcomes were examined using Spearman’s correlation.
Results: Among 131 participants (schizophrenia, n=69; control, n=62), the median HALP index was significantly lower in the schizophrenia group (51.88 [18.89–116.69]) compared with controls (63.47 [31.57–167.54]; p

Key words: Schizophrenia, hemoglobin–albumin–lymphocyte–platelet, C-reactive protein, biomarker