Abstract

Background: POEMS syndrome is a rare neoplastic entity. It has population incidence of 0.3/100,000 and presents predominantly on the 5th or 6th decade of life. Its treatment is considered to be multidisciplinary. Case summary: We present the case of a 47 year old male patient with POEMS syndrome who was initially managed with chemotherapy but was treated with stereotactic radiation therapy for spinal cord compression associated due to a plasma cell neoplasm at the T6-T7 vertebral body. Conclusion: Radiation therapy is the preferred treatment modality for one to three isolated bone lesions, with a marked improvement in neuropathy.

Key words: Fractionated Stereotactic radiotherapy, POEMS Syndrome, spinal cord compression