The aim of this study was to explore the anti-inflammatory and anti-cancer activities of araloside A. Araloside A has a low antioxidant activity. Based on cytotoxicity results, LPS-stimulated macrophage cells were treated with 0500 μM of araloside A, a concentration range that did not reduce the viability of macrophage cells. Araloside A inhibited the production of NO in the macrophages in a concentration-dependent manner. In particular, the 500 M of araloside A reduced NO production to less than the basal level of NO in macrophage cells. Araloside A showed cytotoxicity against the stomach cancer cell lines, SNU-638 and AGS. Additionally, the melanoma cell line B16-F1 was susceptible to araloside A-mediated cytotoxicity. However, the araloside A did not cause cytotoxicity in the ovary cancer cell line NIH:OVCAR-3. Taken together, our results indicate that the araloside A had the anti-inflammatory activity inhibiting NO production and anticancer activity against SNU, AGS cancer cells and melanoma cells, in spite of its low antioxidant activity. These results provide the fundamental information for araloside A as agent against both inflammation and cancer.
Key words: Anti-inflammation, anticancer, araloside A, Aralia elata,
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