Pomegranate peel is widely used in the Middle east as a herbal medicine. However, their action as hepatoprotcetional agents still remains to be clarified, To understand its influence on liver vital functions, Fifty-seven male rats aged 1315 weeks were divided into 15 categories at random including 5 rats per category, and were injected with either TAA, or administered PP plus injected TAA or administered Selenium plus injected TAA or administered with 0.9 percent normal saline solution as a control. The hepatoprotective effect of herbs was evaluated by measuring levels of serum marker enzymes such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and measurement Hepatocyte growth factor(HGF). The histological studies were also carried out to support the above parameters by using special stain Masson tricome and using immunofluorescent staining to examination the distribution of agrin in liver. The study found that the supplementation of pomegranate peel significantly (p < 0.05) reduced the damaging effects on the liver by TAA. ALT, AST, and HGF levels declined in treatment group due to the hepatic injury induced. A comparative histopathological research of the liver show between different groups demonstrated that pomegranate peel drive to normal liver architecture suggesting they may use as hepatoprotective alternative medication.
Key words: TAA Thioacetamide PP pomegranate peel HGF Heptocyte growth factor
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