Abstract

Objective: To determine the role of serum interleukin-6 (IL-6), homocysteine (HCY) and total cholesterol (TC) in normal weight (NW) and overweight (OW) adult men with type 2 diabetes mellitus (T2DM).
Methodology: Adult with normal weight and overweight men with T2DM (n:192, age: 35-40 years) and control men (n:194, age: 35-40 years) in the present case-control observational study investigation were categorized into four sub-groups: NW non-diabetics (NW-ND, n:92, BMI:18.5-24.9 kg/m2), NW diabetics (NW-DM, n:92, BMI:18.5-24.9 kg/m2), OW-ND (n:102, BMI:25.0-29.9 kg/m2), and OW-DM (n:100, BMI:25.0-29.9 kg/m2). Age and BMI of the participants in all four sub-groups were correlated. Serum IL-6, Hcy, TC, hemoglobin (Hb) and hepcidin (Hp) were determined using the enzyme-linked immunosorbent assay (ELISA) kits.
Results: Serum IL-6, Hcy and TC showed highly significant variations (p

Key words: Body mass index, diabetes mellitus-type 2, hepcidin, homocysteine, interleukin-6, overweight adult men, total cholesterol.