Abstract

Background:
Cordarone, a benzofuranic-derivative iodine-rich medication primarily used for tachyarrhythmias, frequently induces alterations in the peripheral metabolism of thyroid hormones, predominantly by inhibiting 5'-deiodinase activity, resulting in elevated serum thyroxine and reverse triiodothyronine levels, alongside diminished serum triiodothyronine concentrations. Overt thyroid dysfunction, which manifests as either cordarone-induced thyrotoxicosis (AIT). Linseed oil or flaxseed oil is a type of oil that comes from seeds. It is one of the oldest oils on the market. Solvent-processed flaxseed oil has been used as a drying oil in painting and varnishing for hundreds of years. Raw oil is utilized as an astringent in fungicidal lotion. It also acts as an insecticide and has some insect-repelling effects.

Aim:
The study sought to show the therapeutic effects of linseed oil on biochemical parameters in rats against toxic effect of cordarone.

Methods:
In this study we used twenty four adult male rats and splited into three groups :control group :drenched standard nutrition only .Cordarone group :drenched cordarone (100mg/kg/day) orally by gavage .Cordarone+Linseed oil group: rats were drenched Cordarone (100mg/kg/day) and linseed oil(3ml/kg/day) for month .at the end of this experiment the rats were scarified and blood samples were taken from the animals for biochemical parameters (ALT, AST, Troponin, TSH, T3 and T4).

Results:
The data showed the positive effect of linseed in improving thyroid gland, Heart and liver against the toxic effect of cordarone.

Conclusion:
Linseed had a positive effect against toxic effect of Cordarone by enhancing hematology parameters. These findings proved benefit of linseed.

Key words: Biochemical parameters ; Cordarone; Linseed oil; Thyroid disorders.