Abstract

Objective: The aim of the study was to investigate plasma D-dimer concentration in patients with liver cirrhosis with and without ascites and to evaluate the impact of ascites depletion on circulating plasma D-dimer levels. Methods: Sixty patients with liver cirrhosis were recruited and categorized into two groups: cirrhotic patients without ascites in group 1 (n=30) and patients with liver cirrhosis and ascites in group 2 (n=30). D-dimer levels were measured on day of admission, in patients with ascites D-dimer concentration levels were repeated measured after ascites resolution cofirmed by ultrasonography. Results: Mean D-dimer levels showed significant increase in cirrhotic patients decompensated by ascites (626,0±231,08 μg/L) when compared with healthy controls (140,73±49,16 μg/L, p

Key words: liver cirrhosis, ascites, D-dimer, hyperfibrinolysis, abdominal paracenthesis