Background: Systemic Scleroderma is a rare disease of connective tissues. It involves rare complications including TTP and SRC, which are similar in presentation.
Case Presentation: The present case presents a 44-year-old female with SSc and combined complication. History was taken from the patient, several investigations and examinations were performed to confirm SSc, and to identify the accompanied complication. Lab investigations, kidney biopsy, CT scan, ECHO, X-ray, physical examination, cardiovascular, respiratory, and gastrointestinal examinations were performed, and SSc accompanied by idiopathic TTP was confirmed in the patient.
Conclusion: TTP is an indication of early SSc and identifying TTP from SRC requires accurate investigations.
Key words: Systemic sclerosis, Thrombotic Thrombocytopenic Purpura, Idiopathic TTP, case report