The present research work was successful in improving the efficacy of zolpidem tartarate oral therapy as the drug release was extended for twelve hours thus reducing dosing frequency there by improving patient compliance. The study also revealed the applicability of HPMC K100M, guar gum and xanthum gum as rate-controlling polymers in matrix tablets. It may be concluded from the study that, formulation F7 (containing 10 mg of xanthum gum) has showed zolpidem tartarte release over a period of 12 h.
Key words: Zolpidem tartrate, Natural gums, HPMCK100M matrix tablets and direct compression.
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