Objective: To investigate the differential expression of the enzymes CYP27B1 (vitamin D-activating) and CYP24A1 (vitamin D-degrading) in breast cancer and normal breast tissues with associations of tumor characteristics, including stage, grade, size, and lymph node involvement.
Methodology: This cross-sectional study included 160 breast tissue samples (80 malignant, 80 normal), for the genes and protein expression analysis of CYP27B1 and CYP24A1 enzymes. Statistical analyses were performed to determine correlations between enzyme expression and clinic-pathological parameters.
Results: There was a significant overexpression of CYP24A1 in breast tissues (p
Key words: Vitamin D metabolism, CYP24A1, CYP27B1, breast cancer, immunohistochemistry.
|
Download PDF 
Post
