Objective: To explore associations between depressive symptoms, MetS, and selected genetic polymorphisms (NPY, PRL, Chemerin, MC4R) in the Pakistani population.
Methodology: This cross-sectional proof-of-concept study was conducted at Aga Khan University. Data collection included demographic assessments, depression screening using Beck's Depression Inventory (BDI), DSM V, and PHQ9. Genetic analysis was done through DNA extraction, conventional and tetra-arm PCR, and Sanger sequencing. Mutation analysis was conducted using the NCBI database. The Statistical analyses were applied using SPSS version 20. Student t-test was applied to assess differences in mean. Chi-square statistics were used for gene frequency. In all instances, p
Key words: Depression, metabolic syndrome, prolactin, neuropeptide Y, chemerin.
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