Abstract

Background:
Bibliometric analysis is a method for analyzing article data, such as those from books and journals. Pharmacokinetic studies are one way to determine the course of drugs in the body, and the irrational use of drugs, especially antibiotics, will cause antibiotic residues and antimicrobial resistance.

Aim:
To assess the pharmacokinetic research trends of norfloxacin and tylosin in poultry and reptiles, bibliometric analyses focusing on pharmacokinetics and antimicrobial resistance are necessary, in as much as improper dosage can lead to increased antimicrobial resistance, especially due to the frequent antimicrobial exposure in these species and the potential public health implications of emerging resistance. This is the first bibliometric analysis on this combination in poultry and reptiles that has not been previously studied.

Methods:
A bibliometric analysis was performed using keywords such as norfloxacin, tylosin, poultry, reptiles, antibiotic residues, antimicrobial resistance, and their combinations. Keywords were recorded in Google Scholar, Scopus, PubMed, and ResearchGate from 2000 to 2023. Visualizing scientific landscapes using VOSviewer version 1.6.20. After a comprehensive review of the entire text, research articles were screened and filtered. Sixty-one research articles were screened in this study.

Results:
Our analysis indicates that bibliometric analyses of the pharmacokinetic interactions between norfloxacin and tylosin in poultry and reptiles have been performed over the last two decades.

Conclusion:
The pharmacokinetics of the combination of norfloxacin and tylosin in poultry and reptiles have shown significant developments over the last two decades.

Key words: Bibliometrics analysis; Norfloxacin; Poultry; Reptiles; Tylosin.