Inflammation is a protective biological reaction against infection and has undesirable effects. Although bergenin (BG), a C-glycoside derivative of 4-O-methyl gallic acid, has many pharmacological properties, no study has demonstrated the activity of BG in inflammatory mediators such as histamine and prostaglandin E2 (PGE2). The present study investigated the anti-inflammatory activity of BG obtained from Peltophorum dubium Taub, in edema models induced by carrageenan and inflammatory mediators in swiss mice. The assessment of its toxicity was also conducted. The evaluations of this study indicated that pretreatment with BG (25 mg/kg) significantly reduced edema induced by carrageenan, compound 48/80, histamine, and PGE2 (p
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