Gender disparities in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): An analysis of biochemical profile, severity of fibrosis and dietary pattern

RMJ. 2026; 51(3): 671-676

Sabhita Shabir Shaikh, Badder Hina Afnan, Shazia Siddiqui, Hafeez Ullah Shaikh, Saba Nafay.

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Objective: To compare the metabolic risk factors, anthropometric measures, biochemical parameters. dietary patterns and fibrosis scores (NFS and Fib-4) between males and females with MASLD. Methodology: A total of 322 ultrasonography-confirmed MASLD patients were recruited in this observational study. Patients with advanced comorbidities, pregnancy, malignancies, or other causes of chronic liver diseases were excluded. Data on dietary intake, anthropometric measurements, and laboratory parameters were recorded. NFS and Fib-4 scores were calculated. Results: Of 322 patients, 28.2% were males and 71.7% females. No significant difference was observed in fibrosis score, i.e., Fib-4 (p=0.28) or NFS (p=0.64) between males and females. However, males had significantly greater height, SGPT, ALP, GGT, and RBS (p Key words: Dietary pattern, Metabolic Dysfunction-Associated Steatotic Liver, gender disparities, fibrosis.