Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles
 

Open Access

Original Article

AJVS. 2017; 55(2): 10-18


Acute and Sub-Chronic Toxicological Potential of Withania Somnifera Extract on Rats

Yehia A. Hussein, Saad S. Al-Shokair, Khaled M. Ashry.

Abstract
Withania somnifera (WS) has a wide range of therapeutic applications for several disorders. Toxicity studies on WS are very limited. The purpose of the present work is to study the acute and sub-chronic toxicity of WS extracts in rats and to determine the LD50 value, which helps in determining the safe dose range for the plant extract to be used with no harmful or lethal effects on the animal. Rats in the acute study were IP injected with the alcoholic extract of WS (the arial parts) at doses of (0), 150, 300, 600 and 1200 mg/kg bwt. In sub-chronic toxicity study, WS extract was administered IP at a dose of 10%, 20% and 40% of the obtained LD50 (52 mg/kg bwt, 104 mg/kg bwt and 208 mg/kg bwt respectively) for 60 days. Acute toxicity revealed an IP LD50 of 522 mg/kg wt. Significant changes in body weight, hematological, biochemical and histopathological were recorded in 20% and 40% LD50 groups with 15 – 40 % mortalities respectively, by the end of the experiments. Based on this study, WS showed toxicity at doses higher than 10% LD50 when given IP and it was recommended to use ≤ 10% LD50 (IP) doses of WS extracts, than the tested here to start within setup protection or treatment studies.

Key words: Keywords: Withania somnifera, lethal dose fifty, sub-chronic toxicity, albino rats.



Similar Articles

Dendritic spine density changes and homeostatic synaptic scaling: a meta-analysis of animal studies.
Moulin TC, Rayêe D, Schiöth HB
Neural regeneration research. 2022; 17(1): 20-24

Effects of electroacupuncture on pain sensation in a rat model of hyperalgesia with nicotine dependence.
Wang SJ, Zhang YP, Candiotti KA
Neural regeneration research. 2022; 17(4): 905-910

Stroke recovery enhancing therapies: lessons from recent clinical trials.
Rogalewski A, Schäbitz WR
Neural regeneration research. 2022; 17(4): 717-720

The missed disease? Endometriosis as an example of 'undone science'.
Hudson N
Reproductive biomedicine & society online. 2022; 14(): 20-27

Exploration of the mechanism by which icariin modulates hippocampal neurogenesis in a rat model of depression.
Zeng NX, Li HZ, Wang HZ, Liu KG, Gong XY, Luo WL, Yan C, Wu LL
Neural regeneration research. 2022; 17(3): 632-642


Full-text options


Latest Statistics about COVID-19
• pubstat.org


Add your Article(s) to Indexes
• citeindex.org






Covid-19 Trends and Statistics
ScopeMed.com
CiteIndex.org
CancerLine
FoodsLine
PhytoMedline
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.



ScopeMed Web Sites