Abstract

Oxidative stress plays a pivotal role in diabetes-induced complications including injurious effect on male reproductive organ. Hibiscus sabdariffa Linn. or roselle possesses antioxidant properties and widely used to treat various diseases. The study was aimed to evaluate the effect of H. sabdariffa polyphenol-rich extract (HPE) from the calyces towards male reproductive organs in diabetic rats. Twenty-four male rats were divided into three groups; (i) normal non-diabetic (NDM), (ii) diabetic (DM) and (iii) diabetic treated with HPE (DM+HPE) groups. Diabetes was induced with streptozotocin (60 mg/kg, single i.p.). HPE (100 mg/kg) was administrated by forced feeding for 28 consecutive days before being sacrificed to harvest their reproductive organs. Results showed that superoxide dismutase (SOD) and catalase (CAT) activity as well as gluthathione (GSH) level in the testis homogenate of DM+HPE group were significantly higher (p

Key words: Diabetes mellitus Type 1, roselle, male reproductive organs, oxidative stress