Cardiotoxicity can be an important adverse effect of some psychotropic drugs. But cardiac side effects with the mirtazapine that is used effectively treatment of depression and anxiety, are rare. In this paper, we describe a case in which a 48 year-old depressive woman treated with single dosage of mirtazapine who presented marked a sinus bradycardia 33 beat/min. Atropine and theophylline were given, in emergence service and the patient was hospitalized and followed up, on cardiology clinic. On the thirty-six hours, her heart rate was normal. To the best of our knowledge this is the first report of bradycardia following treatment with single dosage of mirtazapine. Because the risk factors for mirtazapine-induced bradycardia are unknown we suggested that clinicians should be aware of it, particularly in patients with known underlying heart disease when prescribing mirtazapine.
Key words: Bradycardia, mirtazapine, side effect.
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