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Original Article

J App Pharm Sci. 2018; 8(5): 119-128


Biosynthesis Physico-Chemical Optimization of Gold Nanoparticles as anti-cancer and synergetic antimicrobial activity using Pleurotus ostreatus fungus.

Ehab B. El Domany, Tamer M. Essam, Amr E. Ahmed, Ahmed A. Farghali.



Abstract
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Biosynthesis of nanoparticles is a valuable method and highly safe with low cost. Gold nanoparticles have enormous medical application, in recent days. This study demonstrates an optimized biosynthesis for stable gold nanoparticles (AuNPs) using Pleurotus ostreatus extracellular filtrate. The synthesized gold nanoparticles were characterized using UV- Vis spectrophotometer, Zeta seizer, X-ray diffraction, TEM and FTIR. UV- Vis spectra of gold nanoparticles showed an absorption peak at around 550 nm .From the TEM images the size of AuNPs was found to be about 10-30 nm. The physicochemical parameters of gold nanoparticles biosynthesis were studied using Plackett-Burman design. All parameters were highly significant (p

Key words: Biosynthesis, Plackett-Burman, gold nanoparticles, anti-cancer, synergic

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