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Original Research

Evaluation of rationality of antimicrobial and antidiarrheal fixed dose combination available in Indian market

Anuradha S Joshi, Rajvi K Shah, Mona H Suthar, Unnati H Keharia.


Background: Literature reports growing concern on ever-burgeoning list of irrational fixed dose combinations (FDCs) flooding the Indian market. Current study addresses availability and rationality of two most common group of FDC used clinically, that is, antimicrobial (AM) and antidiarrheal (AD).

Aim and Objective: Analysis of rationality of AM and AD, FDCs, and available in Indian market.

Materials and Methods: AM and AD, FDCs listed in Indian Drug Review 2017 and 2018, were analyzed using a validated eight- point criteria tool.

Results: Out of 138 FDCs, 102 (73.91%) belonged to AM group and 36 (26.08%) belonged to AD group. Out of 102 AM FDC’s, 46 (45.09%) were rational and 56 (54.90%) were irrational. Out of 36 AD, FDCs, 10 (27.77%) were rational and 26 (72.22%) were irrational. Mean rationality score of AM and AD, FDC’s, was (7.72 ± 0.33) and (7.5 ± 0.78), respectively.

Conclusion: Analysis reveals that a number of FDCs available in Indian market is irrational.

Key words: Fixed Dose Combination; Antimicrobial; Antidiarrheal; Irrational; Indian Market

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