Abstract

Sexual side effects are common with antidepressant use. Spontaneous orgasms without sexual arousal have been previously described with several antidepressants. We report the case of a woman who had spontaneous orgasms after starting 300 mg/day bupropion extended-release. Spontaneous orgasms ceased 4 days after stopping the bupropion extended-release. Bupropion extended-release is a norepinephrine-dopamine reuptake inhibitor. Norepinephrine and dopamine related mechanisms may have induced spontaneous orgasms. This unusual side effect should be questioned, particularly in patients who recieve bupropion; otherwise, this side effect may cause embarrassement and noncompliance.

Key words: bupropion; bupropion extended-release; spontaneous orgasm; postmenopausal woman.