The increasing report on antimalarial resistance leads to the development of alternative drug from many resources. Leea indica is a medicinal plant commonly used as an anti-malaria by some Indonesian. The study aimed to evaluate the antioxidant and the antimalarial activity of L. indica. L. indica leaves were extracted in three different solvents (n-hexane, ethyl acetate, and methanol) and assessed for total phenolic, flavonoid and antioxidant activity. The antimalarial activity has been evaluated using the 4-day suppresive antimalarial assay in Plasmodium berghei-infected mice. The methanolic extract yielded the highest fraction of total phenolic and flavonoid, and it also showed the strongest antioxidant activity with the IC50 of DPPH scavenging effect 1.62 + 0.02 μg GAE/ml and the highest percentage of inhibition for hydroxyl radical, 57.60 + 2.52 %. Treatment with methanolic extract of L. indica 50, 100 and 200 mg/kg BW in malaria-mice models significantly (P < 0.05) decreased the MDA and increased the SOD level. The methanolic extract decreased parasitaemia level by 3.50 + 1.26 % on the day fourth and yielded 24.85 + 1.28 % of suppression. The L. indica leaf extract showed an antioxidant activity and could be considered as an antimalarial agent.
Key words: antimalarial, antioxidant, Leea indica, malaria-mice model
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