In above research work ligand based pharmacophore modeling approach is utilized to virtually prepare the molecules for inhibition of phosphodiesterase (PDE5A). The selected compounds were virtually screened and then docking interaction were determined into the active site of PDE5A. The combinations of the pharmacophore modeling, virtual screening, and molecular docking positively give possible inhibitors that can have endless influence for various experimental studies in vasculature diseases.
Key words: Phosphodiesterases, PDE5A, Vasorelaxation, Pharmacophor, Virtual screening
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