Pembrolizumab and procarbazine have been developed as anticancer agents. This study aimed to evaluate the efficacy of the combination of pembrolizumab plus procarbazine in a case with malignant peripheral nerve sheath tumor (MPNST( for the first time. A 48-year-old man referred to the Clinic of Oncology with complaints of constant abdominal pain for a week that the pathology diagnosis showed MPNST. The pathologist reported spindle cell sarcoma (probably dedifferentiated liposarcoma) with a significant PD-L1 expression-tumor proportion score (TPS): 90%. The patient was treated with six courses bi-weekly pembrolizumab combined with procarbazine that after this treatment, abdominopelvic CT scan showed that his lesions completely were resolved. In conclusion, the combination of pembrolizumab with procarbazine can be a new treatment in the patients with MPNST that in the future studies, the clinicians can check PD-L1 in these patients for better therapeutic aims.
Key words: Malignant peripheral nerve sheath tumor, pembrolizumab, procarbazine
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