Abstract

Objective: To compare the effectiveness of biological and conventional dressings on split-thickness skin grafting (STSG) donor wound healing.
Methodology: This quasi-experimental study with post-test control group design was conducted at the Department of Plastic and Reconstructive Surgery, Dr. Soetomo General Hospital, Surabaya, from April to November 2024. A total of 21 patients who underwent intermediate STSG were included. In each patient, four standard donor wounds measuring 50×50 mm were created on the upper thigh, which were randomly allocated to secretome, bacterial nanocellulose (BNC), freeze-dried human amniotic membrane (FDHAM), and paraffin gauze dressing (PGD) groups. Evaluation was performed on days 7, 10, and 14 postoperatively, including area and percentage of epithelialization, epithelialization rate, pain intensity using Visual Analog Scale (VAS), and infection rate based on swab culture. Statistical analysis used Kruskal-Wallis and Mann-Whitney tests.
Results: The secretome group showed significantly higher epithelialization area and rate compared to FDHAM and PGD at all observation times (p

Key words: Wound healing, Secretome, bacterial nanocellulose dressing (BND), Freeze-dried human amniotic membrane (FDHAM), Epithelialization.