The present study was conducted to study some pharmacodynamics and the possible adverse effects of Phenylbutazone in mature male rats . Haematological , biochemical and histopathological studies were carried out.
Mature male albino rats were used and divided into 3 equal groups each of 15 rats. Rats of the first group were kept as a control and intramuscularly injected with propylene glycol (2 ml ./kg b.wt.) once daily for 3 successive days . Rats of the second group were intramuscularly injected once daily for 3 successive days with Phenylbutazone at a dose of 53.3 mg./kg. b.wt. Rats of the third group were intramuscularly injected once daily for 3 successive days with Phenylbutazone at a dose of 106.6 mg/kg. b.wt .
Five rats from each control and treated groups were killed at 2 nd, 4 th and 8th week from beginning of drug administration to obtain blood, semen and some body organs for examination and evaluation .
The obtained results showed that i/ m administration of different doses of Phenylbutazone to male rats induced a variety of side effects on blood picture, biochemical and the reproductive parameters. Moreover, Phenylbutazone induced many histo-pathological alterations in the reproductive organs, liver and kidney of the treated male rats . Therefore, prolonged administration of Phenylbutazone should be avoided .
Key words: phenylbutazone, Male Rats, Liver functions ,blood picture