Neutrophil-derived oxygen free radicals have been implicated in the aetiology of gastric tissue damage. In this study, the ameliorative effects of Allium cepa on neutrophil infiltration, lipid peroxidation and antioxidant enzyme activities in the ethanol-induced gastric injury were evaluated.
Twenty four adult male Wistar rats were used for this study and divided into four groups; Control, Allium cepa, Allium cepa + Ethanol and Ethanol. Allium cepa was administered (1mL/100g body weight) daily for twenty eight days while 0.2mL of 98% (v/v) ethanol per 23g Body Weight was used to induce gastric damage. Macroscopic measurement of ulcer area, histological examination and biochemical analyses (Malondialdehyde level, Myeloperoxidase (index of neutrophil accumulation), Superoxide dismutase (SOD) and Catalase (CAT) activities were carried out in plasma and gastric tissue.
Ethanol administration significantly (p
Key words: Gastric, Allium Cepa, Neutrophil, Myeloperoxidase
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