Objective
Burn injury is one of the main causes of death by injury worldwide and healing of burn is still a challenge in modern medicine. In present study we investigated the healing effects of n-hexane- dichloromethane (1:1) extract of Onosma bulbotrichum roots on second degree burn wound in rabbit.
Methods
36 Iranian rabbits were used in this study. The rabbits were randomly divided into 6 groups. After creating of standard second degree burn wound on the back of rabbits different treatment modalities were investigated in six groups. Group 1 received no treatment, group 2 was treated with cold cream (vehicle), group 3, 4 and 5 were treated with creams containing 0.5%, 1% and 2% (W/W) of plant extract, respectively. The 6th group served as standard group and was treated with Silver Sulfadiazine. Healing was assessed by the rate of wound healing, and total collagen content of treated skin samples. Histopathological evaluation of wound samples was also performed.
Results
The cream containing 0.5% (W/W) of Onosma bulbotrichum root extract significantly (P
Key words: Burn, Rabbit, Onosma bolbutrichum, Root extract
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