Abstract

As a fat-soluble micronutrient, vitamin D is essential for healthy skin because it affects keratinocyte differentiation, immune function, and extracellular matrix integrity. Skin aging is driven by both intrinsic factors, such as cellular senescence and oxidative stress, and extrinsic factors, particularly ultraviolet (UV) radiation. This review explores the impact of vitamin D on skin aging and age-related dermatological conditions, emphasizing its preventive and therapeutic roles. The relevant research articles were searched by using databases like PubMed, Google Scholar, and Elsevier. The keywords that we used in the search strategy included “vitamin D,” “skin aging,” “photoaging,” “antioxidant properties of vitamin D,” “anti-inflammatory effects of vitamin D,” and “skin aging.” Through this search, 31 articles were included that were published between the years 2016 and 2024. Vitamin D possesses potent antioxidant and anti-inflammatory effects, upregulating antioxidative enzymes and regulating nuclear factor erythroid 2 (related factor) 2 signaling to ameliorate oxidative damage. It also improves DNA repair mechanisms and thereby reduces UV-induced mutations and cellular apoptosis. Vitamin D deficiency appears to modulate the clinical course and immune pathways of various skin diseases, including psoriasis, atopic dermatitis, vitiligo, alopecia areata, seborrheic dermatitis, and rosacea. There have been several clinical studies of vitamin D for the role of correcting these conditions in reducing the severity of disease and improving skin barrier function. Accordingly, oral vitamin D increases systemic levels of vitamin D, while topical formulations such as calcipotriol and calcitriol lysate skin keratinocyte proliferation and inflammation.

Key words: Impact, vitamin D, skin aging, dermatological conditions, review