Introduction: An ideal day-care anaesthetic agent should have rapid smooth induction, hemodynamic stability and provide rapid recovery with minimal intra-operative and post-operative side effects. Both propofol and sevoflurane meet these criteria. The present study investigated the hemodynamic stability and recovery profile while maintaining anaesthesia with sevoflurane as inhalational agent versus propofol as total intravenous anaesthesia during laparoscopic surgeries.
Methodology: This was a prospective study conducted from January to December 2011. Using convenient sampling technique, a total of 50 adult patients of American Society of Anaesthesiologists (ASA) physical status grade I or II, aged between 18-60 years, of either sex, who were scheduled for elective day care surgeries of less than 2-hour duration under general anaesthesia were selected for the study after informed consent. All the patients were randomly allocated into one of the two groups using computer generated random number table. Group I received induction with propofol and maintenance with sevoflurane, while group II was induced and maintained with propofol only. Hemodynamic and recovery profile were then compared.
Results: The baseline demographic analysis showed that the two groups did not differ significantly in age, weight, sex, ASA grade and operative times. During the course of surgery, heart rate was significantly low in group II at 45 to 60 minutes than in group I. Systolic and diastolic blood pressure were significantly low during maintenance of anaesthesia with propofol as compared to sevoflurane. Group I showed significantly shorter time for spontaneous eye opening and recalling names and recognizing surroundings Post-operative nausea and vomiting was significantly low in group II.
Conclusion: The present study concludes that patients in both group were hemodynamically stable. Sevoflurane has the added advantage of providing rapid emergence and recovery of cognitive function. Hence it can be considered as a useful alternative to propofol for maintenance of anaesthesia.
Key words: sevoflurane, propofol, day care laproscopy, anaesthesia
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