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Original Research

RMJ. 2026; 51(1): 238-241


The effect of kebar leaf extract on serum kisspeptin levels and ovarian kisspeptin expression in polycystic ovary syndrome rat model (rattus norvegicus)

Bagus Hibridiawan, Ashon Sa’adi, Widjiati Widjiati.



Abstract
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Objective: To evaluate the effect of Kebar leaf extract on serum levels and ovarian expression of kisspeptin in a PCOS rat model.
Methodology: The study employed a randomized post-test-only control group design with rats as subjects. Rats were divided into three groups: a negative control, a positive control, and a treatment group, each receiving different doses of Kebar leaf extract (1.42 mg/g BW/day). Kisspeptin levels were measured from serum and ovarian tissues after treatment.
Results: Kebar leaf extract significantly increased average kisspeptin levels in rats compared to positive controls (p

Key words: Kebar leaf extract, kisspeptin, polycystic ovary syndrome.

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