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Original Article



Synthesis, Docking studies and Anticancer Activity of New Substituted Pyrimidine and Triazolopyrimidine Glycosides

Wael A. El-Sayed, Ashraf M. Mohamed, Hemat S. Khalaf, Dina S. EL-Kady, May Al-Manawaty.




Abstract

New substituted pyrimidine and triazolopyrimidine derivatives were synthesized. The N3-glycosides of both heterocyclic systems and acyclic oxygenated alkyl derivatives were also prepared. The anticancer activity against human prostatic adenocarcinoma (PC3), human colorectal carcinoma (HCT116) and human breast adenocarcinoma (MCF7) cell lines in addition to their effect on human normal retinal pigmented epithelial cell line (RPE1) was studied. Furthermore, the docking studies revealed good binding affinities for compounds 7, 8, 10 and 12. The results showed the effect of N3-substitution in the pyrimidine ring on the activity of synthesized compounds

Key words: Pyrimidine, triazolopyrimidine, glycosides, Enzyme Docking, anticancer activity






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