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Original Article

Turk J Vasc Surg. 2025; 34(2): 155-63


Glycation Burden and Glycemic Variability: Key Drivers of Chronic Venous Insufficiency Severity and Adverse Outcomes.

Ayhan Muduroglu, Hakan Guven.



Abstract
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Aim: Advanced glycation end-products (AGEs) have been implicated in vascular pathology, but their role in chronic venous insufficiency (CVI) remains underexplored. This study investigated the association between glycated hemoglobin (HbA1c), a surrogate marker of glycation burden, and CVI severity and outcomes.
Material and Methods: This single-center retrospective cohort study included 612 patients with CVI. Patients were stratified by glycation burden: high (HGB; HbA1c ≥6.5%, n=247) and low (LGB; HbA1c

Key words: Chronic venous insufficiency, glycated hemoglobin, advanced glycation end-products, venous ulcer, glycemic variability





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09101112
2025

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