Background: Hypovitaminosis D has been reported as a risk factor for glucose intolerance. Although traditionally named as sunshine vitamin, in India, it is paradoxically deficient. Obesity is frequently associated with insulin resistance (IR) and prediabetes and other components of metabolic syndrome. Obesity is also commonly associated with hypovitaminosis D due to the capacity of adipose tissue to store 25-dihydroxy vitamin D making it biologically unavailable.
Aims and Objectives: This study is designed to know the prevalence of hypovitaminosis D and study its relation with IR from Central India.
Materials and Methods: A total of 594 patients were enrolled in the study. Of these, 560 met inclusion-exclusion criteria. Body mass index (BMI), Waist-hip ratio, and blood pressure were measured. Fasting sample was taken for the following investigations: Fasting blood sugar, fasting insulin, intact parathormone, lipid profile, and vitamin D were done. Homeostatic model assessment (HOMA-IR) was calculated. Based on BMI, they were divided into two groups: Cases (n = 168) with BMI >25 and controls (n = 392) BMI
Key words: Vitamin D3; Insulin Resistance; Hypovitaminosis D; 1,25-dihydroxy Vitamin D3
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