A liquid chromatography-tandem mass spectrophotometric (LCMS/MS) method was developed for quantification of Alogliptin in rabbit plasma employing Liquid-Liquid extraction technique. Developed method was validated for specificity, precision, accuracy, recovery, and stability characteristics. Chromatographic separation was achieved on Inertsil ODS 5µm C18, 50×4.60mm with 30:70 v/v of 0.1%formic acid: Organic Mixture (acetonitrile : methanol, 80:20%v/v) as an isocratic mobile phase with a flow rate of 1.0 ml/min. the developed LC-MS method was applied to assess pharmacokinetics parameters of alogliptin tablet in healthy rabbits. Alogliptin showed Tmax of 2.6 ± 0.37 h and mean Cmax, AUC0t and AUC0 for test formulation is 90.6 ± 4.41, 1675.41 ± 164 and 3726.47 ± 796 respectively.
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