Antioxidant and anti-inflammatory actions of crocus sativus linn (saffron) in relation to intensive exercise need to be studied. This study aimed to investigate the effect of four weeks of saffron supplementation on serum levels of tumor necrosis factor alpha (TNF-α), as a marker of inflammation, malondialdehyde (MDA), as a marker of lipid peroxidation, and levels of Lactate dehydrogenase (LDH) and creatine kinase (CK), as two markers of muscle damage, in sedentary women following intensive exercise. For this purpose, forty healthy inactive young womens were randomly assigned into control (C), supplementation (S), resistance exercise (RE), and resistance exercise + supplementation (RE+S) groups. After a 4-week period of supplementation (30 mg/day), the subjects performed one bout of acute resistance exercise at 85 % of one-repetition maximum (1-RM) at 8 stations (bench press, leg press, seated rows, overhead press, seated leg press, arm extension, arm curls and calf raises), each for 3 sets. Using commercial kits, TNF-α and MDA levels were measured using ELISA method. In addition, LDH and CK were measured by photometric method. Data were statistically analyzed by one-way ANOVA and followed by Tukey's post-hoc (P
Key words: Saffron supplementation, Intensive resistance exercise, Tumor necrosis factor alpha, Malondialdehyde, Lactate dehydrogenase, Creatine kinase, Inactive women
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