Abstract

Formulation scientists are faced with a great hurdle of delivering a therapeutic agent into the periodontal pockets, because of the anatomical complexity of the route and the lesion’s contours that often leads to poor penetration of the drug to the area. However, recent nanotechnology advancement and innovations through nanodentistry, are increasingly providing a suitable solution for the treatment of many dental disorders including periodontal disease. These nanodentistry innovative approaches have vowed to revolutionize dental therapeutics by way of using nanomaterials, biotechnology, and nanorobotics, that can significantly influence and transform dental disease’s diagnosis, prevention, and treatment. The advances have offered possibilities for providing high-quality dental care to a vast number of people around the globe who are currently suffering from periodontal disease. Novel nanotechnology-based carriers and materials such as polymeric nanoparticles, nanogels, nanopores, nanotubes, scaffold matrices, nanoneedles, nanocrystals, quantum dots, nanofibers, and nanofillers have demonstrated promising efficacy and their roles in the disease therapy are of great significance. The aim of this review article is to provide important recent updates on the various nanotechnology-base approaches for periodontal disease therapy. The roles of these recently investigated approaches in the disease treatment are also covered in the review.

Key words: Nanotechnological approaches; Nanodentistry; Periodontal disease; Periodontitis; Nanoparticulate Drug Delivery Systems