Abstract

Background: Advanced maternal age is considered a high-risk category in pregnancy. Elevated levels of uric acid, BMI, and blood pressure are associated with an increased risk of proteinuria. However, data on the predictive value of these factors for proteinuria in advanced pregnant women remains limited. Objective: The aim of this study was to determine the optimal cut-off points for uric acid levels, BMI, SBP, and DPB in predicting increased proteinuria in advanced maternal age pregnancies. Methods: A cross-sectional and longitudinal descriptive study was conducted on pregnant women who visited the Obstetrics Department of Vinh Long General Hospital from November 2022 to October 2023. Results: A total of 100 pregnant women were included in the study, with a mean age of 38.6 ± 4.7 years. The prevalence of smoking and alcohol consumption was 18.0% and 20.0%, respectively. Overweight and obesity, smoking, and alcohol consumption were associated with increased proteinuria. Pre-pregnancy BMI with a cutoff point of 22.5 kg/m² showed the highest predictive value for proteinuria, with an AUC of 0.89, sensitivity of 86.2%, and specificity of 92.3%. Conclusion: Overweight and obesity, smoking, and alcohol consumption are identified as risk factors for increased proteinuria. Additionally, blood uric acid levels, pre-pregnancy BMI, systolic blood pressure, and diastolic blood pressure all demonstrate strong predictive value for increased proteinuria in advanced maternal age pregnancies.

Key words: Advanced maternal age, prediction, increased proteinuria, blood uric acid, body mass index, blood pressure.