The effect of exposure of celecoxib and lansoprazole on antioxidant enzymes and lipid peroxidation has been studied in liver of rats. We considered the content of malondialdehyde (MDA), and activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR). The increase of SOD activity after administration of celecoxib in the liver was 29% and observed decrease of CAT (12%), GPx (5%), GR(33%) activities. Similarly, an increase in the antioxidant enzymes was found after administration of celecoxib and lansoprazole such as increase of SOD activity (44%) and decrease of CAT (16%), GPx (9%) and GR activities (46%). The current study shows that exposure of celecoxib and lansoprazole increases the endogenous antioxidant defense system and decreases the lipid peroxidation in rat liver tissues under epinephrine-induced stress and confirms the important role of these drugs in the reduction of stress-induced cellular toxicity.
Key words: celecoxib, lansoprazole, oxidative stress, liver.
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