Gallium-68 labeled prostate-specific membrane antigen (Ga-68 PSMA) positron emission tomography-computed tomography scan (PET/CT) imaging has profoundly transformed prostate cancer diagnosis and management in nuclear medicine practice in recent years. This letter briefly addresses its diagnostic superiority, therapeutic impact, adherence to current guidelines, and practical insights into its application in Türkiye.
Firstly, Ga-68 PSMA PET/CT has demonstrated considerable diagnostic superiority compared to conventional imaging modalities such as CT, magnetic resonance imaging (MRI), and bone scintigraphy. The prospective multicenter ProPSMA trial illustrated significantly higher accuracy for Ga-68 PSMA PET/CT (92%) compared to conventional imaging (65%) in identifying metastatic prostate cancer, representing a clinically significant improvement (27% absolute difference, p
Key words: Ga-68 PSMA PET/CT, prostate cancer, theranostics, diagnostic accuracy
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