Abstract

Objective: This study aimed to assess the knowledge, attitude, and prescribing patterns of GLP-1 receptor agonists (GLP-1 RAs) among cardiologists in the Makkah region of Saudi Arabia.
Methods: A cross-sectional survey was conducted among 75 cardiologists. The questionnaire explored demo graphics, familiarity with GLP-1 RAs, awareness of cardiovascular outcomes trials (CVOTs), attitudes toward use, prescribing behavior, and barriers.
Results: Most participants were males (85%) and were aged 35–44 years (40%), with over 10 years of cardiology practice. While 60% were frequently involved in diabetes care, only 33% had ever prescribed GLP-1 RAs). Semaglutide (67%) was the most recognized agent, and 27% of cardiologists were unfamiliar with any GLP-1 RA. Familiarity with CVOTs was low, with just 20% aware of trial results. Confidence in prescribing was limited, with only 13% feeling very confident. Key barriers included lack of familiarity (47%), cost (40%), safety concerns (27%), and limited formulary access. Most cardiologists (55%) agreed GLP-1 RAs should be used more frequently, but 45% remained unsure.
Conclusion: Despite strong evidence and favorable attitudes, the use of GLP-1 RAs among cardiologists remained low due to educational and systemic barriers. Expanding access, strengthening clinical education, and encouraging multidisciplinary integration are essential to improve uptake in cardiology practice.

Key words: GLP-1 receptor agonists, cardiovascular disease, cardiologists, prescribing patterns, Saudi Arabia