Coronary artery disease (CAD) is a worldwide public health problem with high morbidity and mortality. There is evidence from recent studies that Gamma-glutamyltransferase (γ-GT) is likely to be associated with CAD. However, no studies to date investigated the association of γ-GT with CAD in Sudanese patients. This study aimed to assess the lipid profile level and γ-GT activity of Sudanese patients with CAD. A cross-sectional study was performed in which 60 clinically diagnosed patients and 60 apparently healthy (control group) were enrolled. Serum total cholesterol (TC), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C) concentrations and γ-GT activity were measured. The commonest lipid abnormalities in the patients were; reduced TG (77% < 150 mg/dl) and HDL-C (68% ≤ 60 mg/dl) and increased TC, LDL-C and γ-GT in men and women (80% > 200 mg/dl, 72% > 130 mg/dl and > 22 U/l respectively). Statistical significant differences (P < 0.05) were present in the TC, TG, HDL-C, LDL-C and γ-GT concentration between the case and the control group. Our findings suggest that dyslipidemia is common among Sudanese patients with CAD. Gamma-GT will be an important component of future early predictor biomarker to CAD.
Key words: Coronary artery disease (CAD). Gamma-glutamyltransferase (γ-GT). Lipid profile.
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