Home|Journals|Articles by Year|Audio Abstracts

Original Article

AJVS. 2016; 51(1): 198-206

Myelin Basic Protein is Down-Regulated in Sheep Affected with Ovine Coenurosis

Mohammed Elbeskawy, Mohamed El-Adl, Mohamed Hamed, Mayar Ali and Moustafa Al-Araby.


Ovine coenurosis is a disease condition characterized by nervous manifestations that is associated with severe economic losses for sheep farm owners. This study was conducted to investigate the expression of myelin basic protein (MBP) gene in various regions of the brain in affected animals at different ages. We also studied the prevalence of coenurosis in Dakhlia governorate with parasitological and electron microscopic examinations to evaluate the severity of infestation. Ourresults revealed that MBP expression was down regulated in all brain regions at different ages. A hundred-fold reduction in MBP expression wasobserved in the cerebral cortex and a 500-fold decrease was observed in sheep older than one year. However, no differences were observed in MBP expression at different ages or different brain regions. Moreover, the highest prevalence of ovine coenurosis in Dakhlia governorate was in Belqas city in sheep aged more than 12 months with the highest incidence in the cerebral cortex. Electron microscopic examination revealed demyelination in nerve tracts with the existence of gitter cells indicating the severity of coenurosis. From these results, we concluded that MBP is down-regulated in sheep affected with coenurosis and could serve as a novel marker for ovine coenurosis and other demyelinating diseases in sheep.

Key words: Ovine, Coenurosis, parasitic diseases, myelin basic protein

Full-text options

Share this Article

Online Article Submission
• ejmanager.com

ejPort - eJManager.com
Review(er)s Central
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.