Aim: The article highlights problematic issues of surgical treatment of mechanical complications of acute myocardial infarction (AMI), specifically, post-myocardial infarction ventricular septum rupture (post-MI VSR). Based on the study of the results of surgical treatment of post-MI VSR in patients with different terms of surgical intervention upon AMI evolvement, the most rational approach to ventricular septum defect (VSD) repair in such patients has been determined. Specifically, subject to hemodynamic stability in patients with post-MI VSR within the first two weeks after AMI evolvement, given the risk of mortality (42.1%), the wait-and-see tactics of surgical treatment is deemed a wise measure. Since the third week after AMI the stabilization of operative mortality rate (up to 10.5-15.8%) has been observed this lays the grounds for active surgical treatment tactics. Notably, analysis of the dynamics of echocardiographic characteristics and changes in the degree of tolerance to physical activity (PA) in patients with post-MI VSR who underwent surgery in different periods after AMI evolvement have been particularly addressed. It has been found that the probability of achievement the most favourable clinical condition corresponding to class I by New York Heart Association (NYHA) classification (χ2 (2, n=65) = 20,791; p
Key words: Post-myocardial infarction ventricular septum rupture, acute myocardial infarction, coronary artery atherosclerosis, ischemic heart disease
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