Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles

Open Access

Original Article

AJVS. 2017; 54(1): 117-126

Potential Ameliorative Effects of Alpha Lipoic Acid and Silymarin on Thioacetamide-Induced Hepatic Damage in Rats

Alyaa R. Salama, Samah S. Oda, Asmaa F. Khafaga, Mohamed A. Hashem.

The present study was designed to study the protective effects of alpha lipoic acid (ALA) and silymarin (SIL) against thioacetamide (TAA)-induced hepatic damage. Sixty male albino rats were divided into 6 groups (10 rats each); control group, TAA-treated group: injected intraperitoneally with TAA 250 mg/kg bwt/day three times a week, ALA-treated group: received ALA 100 mg/kg bwt/day) orally three times a week, SIL-treated group: received SIL 100 mg/kg bwt/day orally three times a week, TAA+ALA-treated group, and TAA+SIL-treated group at the same previous doses and routes for ten weeks.
Results showed that TAA induced a significant increase in serum liver enzymes, total and direct bilirubin, total cholesterol and triglycerides levels after four and ten weeks of the treatments. While the serum levels of total proteins, albumin and high density lipoprotein-cholesterol revealed a significant decrease. TAA injection resulted in an increase in the hepatic lipid peroxidation and decreased antioxidant biomarker levels. Histopathologically, TAA revealed marked degenerative, necrotic and fibrotic alterations in the liver, particularly during ten weeks post-treatment. ALA and SIL- treatment ameliorated TAA-induced oxidative damage, alterations in the liver function tests and liver histopathology. However, ALA demonstrated better hepatic protection against TAA-induced liver damage as compared to SIL. The study clearly concluded that ALA has more powerful antioxidant properties than SIL.

Key words: liver, thioacetamide, silymarin, alpha lipoic acid, rats.

Similar Articles

Promoter CAG is more efficient than hepatocyte‑targeting TBG for transgene expression via rAAV8 in liver tissues.
Kang J, Hang L, Zheng W, Luo J, Zhang X, Song Y, Liu A
Molecular medicine reports. 2022; 25(1):

Efficient production of oligomeric chitin with narrow distributions of degree of polymerization using sonication-assisted phosphoric acid hydrolysis.
Zhang X, Mao Y, Briber RM
Carbohydrate polymers. 2022; 276(): 118736

Organelle-inspired supramolecular nanomedicine to precisely abolish liver tumor growth and metastasis.
Zhan J, Wang Y, Ma S, Qin Q, Wang L, Cai Y, Yang Z
Bioactive materials. 2022; 9(): 120-133

Overcoming the limitations of COVID-19 diagnostics with nanostructures, nucleic acid engineering, and additive manufacturing.
Li N, Zhao B, Stavins R, Peinetti AS, Chauhan N, Bashir R, Cunningham BT, King WP, Lu Y, Wang X, Valera E
Current opinion in solid state & materials science. 2022; 26(1): 100966

Hierarchical nickel hydroxide nanosheets grown on hollow nitrogen doped carbon nanoboxes as a high-performance surface substrate for alpha-fetoprotein cancer biomarkers electrochemical aptasensing.
Rahmati Z, Roushani M, Hosseini H
Talanta. 2022; 237(): 122924

Full-text options

Latest Statistics about COVID-19
• pubstat.org

Add your Article(s) to Indexes
• citeindex.org

Covid-19 Trends and Statistics
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.

ScopeMed Web Sites