Abstract

This study aimed to evaluate whether clinical and laboratory findings obtained during the first trimester of pregnancy can serve as early predictors for the development of preeclampsia (PE). This retrospective case-control study included 50 women who developed PE and 50 healthy controls. Demographic characteristics, first-trimester blood pressure, biochemical parameters (thyroid-stimulating hormone [TSH], calcium, uric acid, aspartate aminotransferase [AST], lactate dehydrogenase [LDH]), and inflammatory markers (neutrophil-to-lymphocyte ratio [NLR], platelet-to-lymphocyte ratio [PLR], AST-to-platelet ratio index [APRI], systemic immune-inflammation index [SII]) were analyzed. Women who developed PE were significantly older (33.02±5.73 vs. 29.12±5.94 years, p=0.001) and had higher body mass index (32.95±5.71 vs. 29.17±4.68 kg/m², p=0.001) than controls. First-trimester blood pressures were significantly higher in the PE group: systolic (120.20±18.13 vs. 104±11.43 mmHg) and diastolic (76.80±13.32 vs. 63.20±7.13 mmHg) (both p

Key words: Biological markers, first trimester pregnancy, inflammatory mediators, pregnancy complications, preeclampsia