Backround and objective
To investigate the effect of different doses of sugammadex (4-16 mg) on experimental kidney histopathology in rabbits with acute renal failure.
Methodology
Eight New Zealand White adult male rabbits were used in the study. The rabbits were divided into 2 groups of four. The first group received low dose (4 mg) sugammadex and the second group received high dose (16 mg) sugammadex. Rabbits were administered 20 mg / kg of cisplatin intravenously 4 hours before general anesthesia and an acute renal failure model was established. After general anesthesia was applied, V-GEL RABBIT was placed on all experimental animals to provide airway safety. All experimental animals were manually ventilated using an anesthesia device. At the 25th minute after induction, the rabbits in Group D received 4 mg / kg sugammadex iv, and the rabbits in Group Y received 16 mg / kg sugammadex iv. At the end of the experiment, all experimental animals were sacrificed, and the kidneys were removed, and histopathologic examination was performed.
Result
At the end of our study all experimental animals were sacrificed. There was no statistically significant difference between Group Y and Group D on histopathologic evaluation.
Conclusion
In our study, we hypothesised that using high doses ie. 16 mg / kg sugammadex during general anesthesia after acute renal failure in rabbits would lead to a deteriorated renal histopathology due to the accumulation of rocuronium-sugammadex complex in the tubules. However, we did not observe histopathological differences between the two groups as a result of our study.
Key words: acute renal failure, sugammadeks, rocuronium
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