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Original Research

RMJ. 2025; 50(3): 576-580


Unmasking the role of obesity in COVID-19: Effects on laboratory parameters, inflammatory markers and clinical outcome

Ghazala Jawwad, Ghulam Mustafa Azad Lodhi, Javeria Abbasi, Ramesha Tahir, Arslan Kareem, Maleha Asim.



Abstract
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Objectives: To compare the outcome in obese and non-obese covid positive patients.
Methodology: In this retrospective study, data were obtained from the records of 150 COVID-positive patients, aged 18-80 years, admitted to Railway Hospital Rawalpindi and Riphah International Hospital Sihala from July 2021 to November 2022. Patients were divided into two groups on the basis of BMI. They were categorised into two groups: obese and non-obese. Laboratory parameters parameters, inflammatory markers and outcomes were compared in two groups.
Results: Blood gas analysis revealed significantly higher pCO₂ levels (62.01±21.98 vs 54.35±12.43 mmHg, p=0.011) and lower PO2 in obese as compared to non-obese (62.96±12.07 vs 65.85±11.09 mmHg, p=0.038). No significant differences were observed between the two groups for ferritin, d-dimers, lactate dehydrogenase (LDH) and C-reactive protein (CRP). Obese patients had significantly higher glycosylated hemoglobin (HbA1c) levels (6.98±1.85% vs 6.17±1.64%, p=0.005). Oxygen requirements at discharge and mortality rate were significantly higher in obese as compared to non-obese (1.48±1.3 vs 0.70±1.05 L/min, p

Key words: C- reactive protein, D- Dimers, ferritin, inflammatory markers, obesity, outcome.







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0809101112
2025

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