The aim of the present study is to evaluate the effects of the commonly used honeybee product (propolis) and herbal product (myrrah) in curing the hazardous complications on liver and kidney of diabetic group. The experiment was designed into six groups of adult albino Swiss mice; Control group (C), Diabetic group (D), Propolis (PE) and Myrrha (ME) treated groups (100 mg/kg BW, orally administered for 7 days), and Diabetic group treated with Propolis (DPE) or Myrrha (DME) groups. The study investigated liver and kidneys functions along with histopathological studies, markers for anaemia, tissue interleukins, antioxidants and end product of lipid peroxidation. The present data showed that plasma aspartate transaminase, alanine transaminase, urea and creatinine levels along with conspicuous curing effects in liver and kidneys sections decreased in DPE compared to diabetic group. Modulation of the normocytic/ normochromic anaemia, elevating the tissues Catalase and reducing the superoxide dismutase and malondialdhyde in DPE group. In addition, decrement of IL-6 and increment of IL-10 were detected. Results about treatment with myrrah revealed no improvement in either the liver or the kidneys complications of diabetic mice. The present findings could be considered as a message for diabetic patients to raise their awareness concerning the effectiveness/ineffectiveness of some folk medicine products.
Key words: Propolis, Myrrha, Diabetes, Liver, Kidney, Antioxidants, Anaemia, Interleukins
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