Hypertensives among Malaysians is increased for the last decade. The cost of anti-hypertensive is also escalating. There is a need to find cheaper alternative drugs. In tropical regions, there have been claims that Eurycoma longifolia (EL) a local herbal plant is effective in obliterating headache and reducing blood pressure. Most studies had focused on aphrodisiac property of EL which has been shown to enhance testosterone levels in males. This study explored the possible effect EL as anti-hypertensive agent and the mechanism in relation to testosterone levels. Twenty young, adult male Sprague-Dawley (SD) rats were randomly divided into four groups and treated as follow: ND rats were given only normal diet, NDEL : normal diet and EL extracts (15mg/kg) dissolved in distilled water, HFD : high fat diet and HFDEL: high fat diet and EL extracts. Results showed that there was no significant increase of BP in normal rats taking EL (NDEL) as compared to ND. Treatment with EL extract reduced the systolic and diastolic BP significantly (P
Key words: Hypertension, Eurycoma longifolia, Tongkat Ali, Testosterone, Cardiovascular, Androgen
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